The clinician impact and financial cost to the NHS of litigation over pregabalin: a cohort study in English primary care

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• The drug interaction studies described in this section were conducted in healthy adults, and across various patient populations.
• During an 8-week baseline period, patients had to experience at least 6 partial-onset seizures with no seizure-free period exceeding 4 weeks.
• Among the LYRICA-treated patients, 80% completed the double-blind phase of the studies.
• Keep a list of them with you to show your healthcare provider and pharmacist each time you get a new medicine.
• The safety and efficacy in children and adolescents (under 18 years) have not been established, so pregabalin should not be used in this age group.
• The background of how drug patents operate; the value of generic prescribing and NHS prescribing cost reimbursement are covered in box 1.

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LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles in adult patients. LYRICA is also indicated to treat partial-onset seizures in patients 1 month of age and older with epilepsy who take 1 or more other drugs for seizures. Report behaviors of concern immediately to healthcare providers see Warnings and Precautions (5.3). A pharmacokinetic study in ten lactating women, who were at least 12 weeks postpartum, evaluated the concentrations of pregabalin in plasma and breast milk. LYRICA 150 mg oral capsule was given every 12 hours (300 mg daily dose) for a total of four doses.

Figure 3.

Administration of each daily dose was divided into two equal doses (twice a day dosing). Following is a list of treatment-emergent adverse reactions reported by patients treated with LYRICA during all clinical trials. Table 7 lists all dose-related adverse reactions occurring in at least 2% of all LYRICA-treated cost of lyrica patients.